Toxins can refer to a broad range of harmful substances that negatively affect human health depending on the dose and exposure. Some examples of the toxins Clari removes include microplastics, drug overdoses, PFAS, manmade chemicals, pollution and metabolic waste.
The Clari Procedure is designed to remove things like microplastics, protein-bound toxins, endocrine disruptors, and specific manmade chemicals from your plasma. However, certain heavy metals are bound to red blood cells and only plasma passes through the Clari column.
That said, while the procedure doesn’t directly eliminate heavy metals, it can significantly reduce the systemic stress associated with them, which many patients find beneficial.
The Clari Procedure removes microplastics and other synthetic particles greater than 5 microns circulating in your plasma. These particles are increasingly being detected in human blood, organs, and tissues, and are known to contribute to inflammation, oxidative stress, and overall toxic burden.
As part of your Clari Procedure, we also offer advanced laboratory testing before and after your procedure to measure your circulating microplastics levels. This allows us to quantify your baseline burden and track the reduction following treatment.
We have not specifically tested the ability of the MTx.100 column to remove the spike protein.
However, if you are suffering from long COVID symptoms, the Clari Procedure may be able to provide some assistance by helping to remove circulating toxins associated with post-viral effects.
Yes, Clari does remove many endocrine-disrupting and forever chemicals (for example, paraquat and PFAS) circulating in plasma. While no procedure fully eliminates lifetime of PFAS exposure, Clari offers a powerful way to reduce ongoing circulating burden in the bloodstream.
We have not specifically tested the ability of the MTx.100 column to remove bacteria, viruses or mold, as there are so many individual species. We have performed successful procedures on mild and ICU admitted severe patients across all three infections.
No. Clari is designed to remove what shouldn’t be there while retaining what should. Clari retains most of your circulating antibodies (a large component of your immune system), electrolytes, albumin, coagulation factors, and cell signaling factors to maintain your unique metabolic stability and immunity.
Clari aims to reduce the significant, long-term circulating burden of microplastics.
All regulated and CE-mark approved extracorporeal medical systems (including ours) use sterile, medical-grade polymer components that have been rigorously tested for safety, sterility and biocompatibility. The minimal, highly controlled exposure during a 2 hour procedure is negligible compared to the continuous, involuntary environmental exposure people experience every day over years.
Marker is the medical technology company that developed the MTx.100 plasma adsorption column, the core device used in the Clari procedure. Marker manufactures this CE-marked column, which enables selective adsorption of unwanted components from plasma.
Clarify Clinics, a joint venture with Marker, is the clinic brand that provides the Clari procedure, an elective plasma adsorption procedure designed to remove unwanted components from plasma.
In short:
The MTx.100 column is the same column used for every protocol. No matter your condition, the Clari procedure remains the same, although its frequency is tailored to your unique needs.
Clari is selective subtractive medicine, removing what shouldn’t be there so the body can function optimally. Unlike therapeutic plasma exchange (TPE) where your own plasma is thrown away and replaced with a dilutionary mixture of human-derived albumin and saline, we return your selectively cleaned plasma directly to you. This retains most of your circulating antibodies, electrolytes, albumin, coagulation, and cell signaling factors to maintain your unique metabolic stability and immunity.
While both EBOO (Extracorporeal Blood Oxygenation and Ozonation) and the Clari procedure involve extracorporeal blood circulation, they are fundamentally different in both purpose and technique.
EBOO is a form of ozone therapy on whole blood. The intent is to create an oxidative environment in the blood that is toxic to circulating pathogens. In this procedure, blood is drawn from the body, mixed with ozone and oxygen gas, filtered to remove killed pathogens, and returned to your body. Its regulatory status varies significantly by country.
The Clari procedure, by contrast, does not use ozone or add anything to your blood. It is a plasma only procedure using an selective adsorbent column, specifically the CE-marked Marker MTx.100, which gently removes drug overdoses, toxins and poisons from your plasma. Your selectively plasma is then immediately returned directly to you, intact, minus these removed substances.
Yes. The device we use (the MTx.100 column) has a long clinical history for safely removing drug overdoses and toxins.
The MTx.100 column is a CE Mark approved medical device, with UKCA approval.
The MTx.100 column has an EUA from the FDA for severe COVID-19 patients in the ICU, but does not yet have full FDA market approval.
Safety is always our top priority.
The Clari Procedure uses medically regulated CE-marked filtration technology originally developed for critically ill patients in intensive care units. The device we use (the MTx.100 column) has a long clinical history for safely removing drug overdoses and toxins.
While the Clari Procedure is a novel application of the MTx.100 column, the equipment we use, which is the same equipment used in the ICU, is manufactured according to global regulatory standards for safety, sterility and biocompatibility.
A comprehensive list of risks is outlined in our terms and conditions.
There are risks of infection with any medical procedure. However, all components including all tubing, consumables and columns used during your Clari procedure are completely sterile and single-use disposable. Nothing is ever reused, and your safety is our top priority.
If you’ve had issues with rolling or difficult-to-access veins in the past, it can make cannulation more technically challenging. In these cases, we generally recommend a quick venous access consult beforehand to help determine the best approach and ensure your experience is as smooth as possible.
That said, our team is experienced with these situations and we do use ultrasound-guided access when needed. One of the most helpful things you can do in advance is arrive very well-hydrated, as that greatly improves peripheral vein visibility and access.
Preparation for the Clari Procedure is minimal. We recommend staying well-hydrated, and drinking 2–4 litres of water in the 12 hours before your appointment to assist with IV access. You should eat a well-balanced, low-fat meal 1–2 hours prior to the procedure, and avoid alcohol and caffeine that day.
You can leave the clinic immediately after it’s completed.
Please avoid saunas, ice baths, any infusions, any medical procedures, fasting, HBOT, EBOO, strenuous activity and extended periods of inactivity, as well as any other procedure that is not specifically approved.
The Clari Procedure is generally very well tolerated. Most patients are able to return to normal activities the same day.
Some individuals report feeling lighter, clearer, or more energized shortly after the procedure. Improvements in sleep quality, mental clarity, and overall sense of well-being are also commonly noted in the days that follow. However, everyone’s response is different.
As the body adjusts, some patients may experience symptoms such as fatigue, headache, body aches, or flu-like sensations lasting from a day up to a week. These effects are typically short-lived and resolve without any medical intervention required. Both responses are completely normal and are not a reflection of how effective the procedure was.
After a Clari procedure, we recommend staying well-hydrated, avoiding strenuous activity for 48 hours, remaining gently active by prioritizing movement like walking and avoiding sitting and lying down for long periods of time during your waking hours. Patients will receive simple post-procedure care guidelines, which we will review with you before your appointment.
If you’re planning to travel or have specific scheduling needs post-procedure, please let us know as we have a specific travel policy for 48 hours on either side of the procedure.
Our travel protocol precludes flights longer than 3 hours for 48 hours before and after the procedure.
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